辽宁医学杂志

目的 观察依达拉奉右莰醇联合奥扎格雷钠对大动脉粥样硬化性(LAA)脑梗死患者NIHSS评分、血清CRP、IL-6、TNF-α水平的影响。方法 将我院2023年10月—2024年9月120例LAA脑梗死患者随机分组，对照组60例单用奥扎格雷钠，观察组60例联用依达拉奉右莰醇与奥扎格雷钠，对比神经功能、炎性因子、血液流变学、康复效果、疗效与安全性。结果 研究组CRP、IL-6、TNF-α水平与NIHSS评分、CSS评分、HCT、血小板聚集率、全血高切黏度、全血低切黏低于对照组(P<0.05),研究组Fugl-Meyer评分、MMSE评分、BI指数与总有效率高于对照组(P<0.05);两组不良反应无统计学意义(P>0.05)。结论 依达拉奉右莰醇联合奥扎格雷钠可改善大动脉粥样硬化性脑梗死患者的炎症与神经功能，康复效果与临床疗效显著，安全性高。

Objective To observe the effects of edaravone dextrocamphorol combined with sodium ozagrel on NIHSS score, serum CRP,IL-6 and TNF-α levels in patients with large atherosclerotic(LAA) cerebral infarction.Methods From October 2023 to September 2024,120 patients with LAA cerebral infarction in our hospital were randomly divided into the control group(60 cases) and the observation group(60 cases).The neurological function, inflammatory factors, hemorheology, rehabilitation effect, efficacy and safety were compared.Results The levels of CRP,IL-6,TNF-α,NIHSS score, CSS score, HCT,platelet aggregation rate, whole blood high shear viscosity, whole blood low shear viscosity in the study group were lower than those in the control group(P<0.05),and the Fugl-Meyer score, MMSE score, BI index and total response rate in the study group were higher than those in the control group(P<0.05).There was no statistical significance in adverse reactions between the two groups(P>0.05).Conclusion Edaravone dextrocamphorol combined with ozagrel sodium can improve the inflammation and nerve function of patients with large atherosclerotic cerebral infarction, with significant rehabilitation and clinical efficacy and high safety.